“Human proteome” Core Facility

  Maiorov V.A., Tikhonova O.V., Zgoda V.G. (2025) Circulating protein biomarkers of glioblastoma: methodologic approaches and perspectives of development, Biomeditsinskaya Khimiya, 71(6), 400-413. DOI:10.18097/PBMCR1637

  Andreeva A.M., Lamash N., Martemyanov V.I., Vasiliev A.S., Toropygin I.Yu., Garina D.V. (2024) High-density lipoprotein remodeling affects the osmotic properties of plasma in goldfish under critical salinity, Journal of Fish Biology, 104(3), 564-575. DOI:10.1111/jfb.15607

  Konstantinov M.A., Zhdanov D.D., Toropygin I.Yu. (2024) Quantitative mass spectrometry with 18O labelling as an alternative approach for determining protease activity: an example of trypsin, BIOpreparations. Prevention, Diagnosis, Treatment., 24(1), 46-60. DOI:10.30895/2221-996X-2024-24-1-46-60

  Tarasova N., Zanin A., Ponomarev A., Toropygin I., Krivoborodov E. (2024) Conversion of elemental phosphorus under the electron beam irradiation, Pure and Applied Chemistry, 96(3), 429-436. DOI:10.1515/pac-2024-0027

  Odorskaya M.V., Mavletova D.A., Nesterov A.A., Tikhonova O.V., Soloveva N.A,. Reznikova D.A., Galanova O.O., Vatlin A.A., Slynko N.M., Vasilieva A.R., Peltek S.E., Danilenko V.N. (2024) The use of omics technologies in creating LBP and postbiotics based on the Limosilactobacillus fermentum U-21, Frontiers in Microbiology, 15, 1416688. DOI:10.3389/fmicb.2024.1416688

  Seregina T., Shelomentsev I., Krivoborodov E., Vaniushenkova A., Toropygin I., Dyatlov A., Lukashov N., Dyatlov V. (2024) Physicochemical and Biological Properties of Vancomycin-Containing Antibacterial Polysaccharide Gels, Biomacromolecules, 25(7), 4156-4167. DOI:10.1021/acs.biomac.4c00268

  Epiktetov D.O., Sviridov A.V., Tarlachkov S.V., Shushkova T.V., Toropygin I.Y., Leontievsky A.A. (2024) Glyphosate-Induced Phosphonatase Operons in Soil Bacteria of the Genus Achromobacter, International Journal of Molecular Sciences, 25(12), 6409. DOI:10.3390/ijms25126409

  Melnikova D.N., Finkina E.I., Potapov A.E., Danilova Y.D., Toropygin I.Y., Matveevskaya N.S., Ovchinnikova T.V., Bogdanov I.V. (2024) Structural and Immunological Features of PR-10 Allergens: Focusing on the Major Alder Pollen Allergen Aln g 1, International Journal of Molecular Sciences, 25(9), 4965. DOI:10.3390/ijms25094965

  Mamaeva A., Krasnova O., Khvorova I., Kozlov K., Gursky V., Samsonova M., Tikhonova O., Neganova I. (2023) Quality Control of Human Pluripotent Stem Cell Colonies by Computational Image Analysis Using Convolutional Neural Networks, International Journal of Molecular Sciences, 24(1), 140. DOI:10.3390/ijms24010140

  Onishchenko N.R., Moskovtsev A.A., Kobanenko M.K., Tretiakova D.S., Alekseeva A.S., Kolesov D.V., Mikryukova A.A., Boldyrev I.A., Kapkaeva M.R., Shcheglovitova O.N., Bovin N.V., Kubatiev A.A., Tikhonova O.V., Vodovozova E.L. (2023) Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions, Pharmaceuticals, 15(6), 1754. DOI:10.3390/pharmaceutics15061754

  Tretiakova D., Kobanenko M., Alekseeva A., Boldyrev I., Khaidukov S., Zgoda V., Tikhonova O., Vodovozova E., Onishchenko N. (2023) Protein Corona of Anionic Fluid-Phase Liposomes Compromises Their Integrity Rather than Uptake by Cells, Membranes, 13(7), 681. DOI:10.3390/membranes13070681

  Glushko V.V., Serkova O.S., Kamkina A.V., Isaeva S.A., Toropygin I.Yu., Maslennikova V.I. (2023) Synthesis of Calix[4]resorcinarene and 1,1′-Dinaphthylmethane Amide Derivatives and Their Ability to Extract Metal Cations, Russian Journal of General Chemistry, 93(3), 554-569. DOI:10.1134/S107036322303012X

  Andreeva A.M., Bazarova Z.M., Toropygin I.Yu., Vasiliev A.S., Fedorov R.A., Pavlova P.A., Garina D.V. (2023) Analysis of the composition of osmotically active protein fraction in blood serum from atlantic cod gadus morhua, Journal of Evolutionary Biochemistry and Physiology, 59(2), 90-99. DOI:10.31857/S004445292302002X

  Bolosov I.A., Panteleev P.V., Sychev S.V., Khokhlova V.A., Safronova V.N., Toropygin I.Y., Kombarova T.I., Korobova O.V., Pereskokova E.S., Borzilov A.I., Ovchinnikova T.V., Balandin S.V. (2023) Design of Protegrin-1 Analogs with Improved Antibacterial Selectivity, Pharmaceutics, 15(8), 2047. DOI:10.3390/pharmaceutics15082047

  Luss A., Kushnerev K., Vlaskina E., Vanyushenkova A., Mezhuev Y.O., Krivoborodov E., Toropygin I., Gavryushenko N., Vetrile M., Zaitsev V., Dyatlov V. (2023) Gel Based on Hydroxyethyl Starch with Immobilized Amikacin for Coating of Bone Matrices in Experimental Osteomyelitis Treatment, Biomacromolecules, 24(12), 5666-5677. DOI:10.1021/acs.biomac.3c00653

  Varizhuk I.V., Tsvetkov V.B., Toropygin I.Y., Stomakhin A.A., Kolganova N.A., Surzhikov S.A., Timofeev E.N. (2023) The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer, Pharmaceutics, 15(2), 604. DOI:10.3390/pharmaceutics15020604

  Gromova O.A., Torshin I.Yu., Gromov A.N., Tikhonova O.V. (2023) Nephroprotective peptides of Laennec® in the context of pharmacotherapy for nephro-hepato-metabolic disorders, Farmakoekonomika, 16(4), 570-586. DOI:10.17749/2070-4909/farmakoekonomika.2023.215

  Torshin I.Y., Gromova O.A., Tikhonova O.V., Chuchalin A.G. (2023) Molecular mechanisms of the effect of standardized placental hydrolysate peptides on mitochondria functioning, Therapeutic Archive, 95(12), 1133-1140. DOI:10.26442/00403660.2023.12.202494

  Murzina S.A., Voronin V.P., Churova M.V., Ruokolainen T.R., Shulgina N.S., Provotorov D.S., Tikhonova O.V., Nemova N.N. (2022) The Effects of Low-Level Helium–Neon (He–Ne) Laser Irradiation on Lipids and and Fatty Acids, and the Activity of Energetic Metabolism Enzymes and Proteome in the Blastula Stage and Underyearlings of the Atlantic Salmon Salmo salar: A Novel Approach in Salmonid Restoration Procedures in the North, Biomolecules, 12(1), 133-166. DOI:10.3390/biom12010133

  Tarasova N., Krivoborodov E., Zanin A., Pascal E., Toropygin I., Artyukhov A., Muradyan S., Mezhuev Y. (2022) Formation of Hydrogels Based on a Copolymer of N-Vinyl-2-pyrrolidone and Glycidyl Methacrylate in the Presence of the Reaction Product of 1,3-Dimethylmidazolium Dimethylphosphate and Elemental Sulfur, Gels, 8(2), 136. DOI:10.3390/gels8020136

  Safronova V.N., Panteleev P.V., Sukhanov S.V., Toropygin I.Y., Bolosov I.A., Ovchinnikova T.V. (2022) Mechanism of Action and Therapeutic Potential of the β-Hairpin Antimicrobial Peptide Capitellacin from the Marine Polychaeta Capitella teleta, Marine Drugs, 20(3), 167. DOI:10.3390/md20030167

  Volkov М.А., Fedoseev А.М., Krivoborodov E.G., Toropygin I.Y., Germana К.E., Grigorieva М.S., Kuznetsova V.V., Budantseva N.А., Novikov А.P., Mezhuev Y.O. (2022) A new method for the synthesis of polynuclear carboxylate complexes of technetium (II, III), Journal of Organometallic Chemistry, 957, 122146. DOI:10.1016/j.jorganchem.2021.122146

  Andreeva A.M., Martemyanov V., Vasiliev A.S., Toropygin I.Yu., Lamash N., Garina D.V., Pavlov D. (2022) Goldfish as a model for studying the effect of hypernatremia on blood plasma lipoproteins, Bratislava Medical Journal, 123(3), 172-177. DOI:10.4149/bll_2022_028

  Serkova O.S., Glushko V.V., Toropygin I.Yu., Maslennikova V.I. (2022) Salts or complexes? Factors affecting the type of binding of biogenic organic amines by carboxyl derivatives of 1,1′-dinaphthylmethanes and calix[4]resorcinarenes, Tetrahedron, 117–118, 132834. DOI:10.1016/j.tet.2022.132834

  Nechaeva A., Artyukhov A., Luss A., Shtilman M., Gritskova I., Shulgin A., Motyakin M., Levina I., Krivoborodov E., Toropygin I., Chistyakov E., Gurevich L., Mezhuev Y. (2022) Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel, Polymers, 14(9), 1727. DOI:10.3390/polym14091727

  Biziaev N., Sokolova E., Yanvarev D.V., Toropygin I.Yu., Shuvalov A., Egorova T., Alkalaeva E. (2022) Recognition of 3` nucleotide context and stop codon readthrough are determined during mRNA translation elongation, Journal of Biological Chemistry, 298(7), 102133. DOI:10.1016/j.jbc.2022.102133

  Nechaeva A.M., Artyukhov A.A., Luss A.L., Shtilman M.I., Svistunova A.Yu., Motyakin M.V., Levina I.I., Krivoborodov E.G., Toropygin I.Yu., Chistyakov E.M., Tsatsakis A.M., Gurevich L., Mezhuev Ya.O. (2022) The Synthesis and Properties of a New Carrier for Paclitaxel and Doxorubicin Based on the Amphiphilic Copolymer of N-vinyl-2-pyrrolidone and Acrylic Acid, Macromolecular Chemistry and Physics, 223(17), 2200081. DOI:10.1002/macp.202200081

  Fedulova L., Vasilevskaya E., Tikhonova O., Kazieva L., Tolmacheva G., Makarenko A. (2022) Proteomic Markers in the Muscles and Brain of Pigs Recovered from Hemorrhagic Stroke, Genes, 13(12), 2204. DOI:10.3390/genes13122204

  Ushakova N.A., Tikhonova O.V., Ambaryan A.V., Bastrakov A.I., Dontsov A.E. (2022) A Protein Antioxidant Complex of a Water Extract of the Larvae of Black Beetles Ulomoides dermestoides, Applied Biochemistry and Microbiology, 58(S1), S146-S151. DOI:10.1134/S0003683822100155

  Shumyantseva V.V., Bulko T.V., Tikhonova E.G., Sanzhakov M.A., Kuzikov A.V., Masamrekh R.A., Pergushov D.V., Schacher F.H., Sigolaeva L.V. (2021) Electrochemical studies of the interaction of rifampicin and nanosome/rifampicin with dsDNA, Bioelectrochemistry (Amsterdam, Netherlands), 140, 107736. DOI:10.1016/j.bioelechem.2020.107736

  Krivoborodov E., Motyakin M., Levina I., Dyatlov V., Toropygin I., Dyakonov V., Mezhuev Ya. (2021) The product of interaction of elemental sulfur and dimethylphosphate 1,3-dimethylimidazolium is a new green initiator of formaldehyde polymerization, Green Chemistry Letters and Reviews, 14(2), 435-441. DOI:10.1080/17518253.2021.1926550

  Tarasova N., Zanin A., Krivoborodov E., Toropygin I., Pascal E., Mezhuev Ya. (2021) The New Approach to the Preparation of Polyacrylamide-Based Hydrogels: Initiation of Polymerization of Acrylamide with 1,3-Dimethylimidazolium (Phosphonooxy-)Oligosulphanide under Drying Aqueous Solutions, Polymers, 13(11), 1806-1814. DOI:10.3390/polym13111806

  Ushakova N.A., Brodsky E.S., Tikhonova O.V., Dontsov A.E., Marsova M.V., Shelepchikov A.A., Bastrakov A.I. (2021) Novel Extract from Beetle Ulomoides dermestoides: A Study of Composition and Antioxidant Activity, Antioxidants, 10(7), 1055. DOI:10.3390/antiox10071055

  Novikova S.E., Soloveva N.A., Farafonova T.E., Tikhonova O.V., Liao P.C., Zgoda V.G. (2021) Proteomic Signature of Extracellular Vesicles for Lung Cancer Recognition, Molecules, 26(20), 6145. DOI:10.3390/molecules26206145

  Tarasova N., Krivoborodov E., Zanin A., Toropygin I., Pascal E., Dyatlov V., Mezhuev Y. (2021) Anionic Polymerization of Ethyl 2-Cyanoacrylate Initiated by 1,3-Dimethylimidazolium (phosphonooxy-)oligosulfanide, Macromolecular Research, 29(12), 847-850. DOI:10.1007/s13233-021-9104-6

  Serkova O.S., Glushko V.V., Maslennikova V.I., Toropygin I.Y. (2021) Synthesis of phosphonates immobilized on a polycyclic platform and conjugated with triazole moieties, Russian Chemical Bulletin, 70(7), 1328-1334. DOI:10.1007/s11172-021-3219-y

  Pichkur E.B., Mikirtumov V.I., Sokolova O.S., Tikhonova O.V., Derkacheva N.I., Kurochkina L.P. (2021) Determination of the Near-Atomic Structure of Non-Purified Oligomeric E. coli Proteins, Crystallography Reports, 66(5), 854-860. DOI:10.1134/S1063774521050187

  Khandazhinskaya A.L., Maslova A.A., Matyugina E.S., Kukhanova M.K., Kochetkov S.N., Mercurio V., Ñahui Palomino R.A., Margolis L., Vanpouille C., Novikov M.S., Paramonova M.P., Fedorova N.E., Yurlov K.I., Kushch A.A., Tarasova O. (2021) Dual-targeted anti-CMV/anti-HIV-1 heterodimers, Biochimie, 189, 169-180. DOI:10.1016/j.biochi.2021.06.011

  Mezhuev Y.O., Vorobev I.Y., Plyushchii I.V., Krivoborodov E.G., Artyukhov A.A., Luss A.L., Derevnin I.A., Dyatlov V.A., Alekperov R.A., Shtilman M.I., Korshak Y.V., Motyakin M.V., Kovarskii A.L., Ionova I.S., Toropygin I.Y., Volkov M.A. (2021) Chemical oxidative polymerization of methylene blue: Reaction mechanism and aspects of chain structure, Polymers, 13(13), 2188. DOI:10.3390/polym13132188

  Андреева А.М., Торопыгин И.Ю., Гарина Д.В., Ламаш Н.Е., Васильев А.С. (2020) The Role of High-Density Lipoproteins in Maintaining Osmotic Homeostasis in the Goldfish Carassius Auratus L. (Cyprinidae), Journal of Evolutionary Biochemistry and Physiology, 56(2), 98-107. DOI:10.31857/S0044452920020023

  Maltseva D., Raygorodskaya M., Knyazev E., Zgoda V., Tikhonova O., Zaidi S., Nikulin S., Baranova A., Turchinovich A., Rodin S., Tonevitsky A. (2020) Knockdown of the α5 laminin chain affects differentiation of colorectal cancer cells and their sensitivity to chemotherapy, Biochimie, 174, 107-116. DOI:10.1016/j.biochi.2020.04.016

  Medvedev A., Kopylov A., Buneeva O., Kurbatov L., Tikhonova O., Ivanov A., Zgoda V. (2020) A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research, International Journal of Molecular Sciences, 21(11), 4187. DOI:10.3390/ijms21114187

  Novikova S., Shushkova N., Farafonova T., Tikhonova O., Kamyshinsky R., Zgoda V. (2020) Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines, International Journal of Molecular Sciences, 21, 6601. DOI:10.3390/ijms21186601

  Afoshin A.S., Kudryakova I.V., Borovikova A.O., Suzina N.E., Toropygin I.Y., Shishkova N.A., Vasilyeva N.V. (2020) Lytic potential of Lysobacter capsici VKM B-2533T: bacteriolytic enzymes and outer membrane vesicles, Scientific Reports, 10(1), 9944. DOI:10.1038/s41598-020-67122-2

  Tarasova N., Krivoborodov E., Egorova A., Zanin A., Glukhov L., Toropygin I., Mezhuev Ya. (2020) Reaction of 1,3-dimethylimidazolium dimethylphosphate with elemental sulfur, Pure and Applied Chemistry, 92(8), 1297-1304. DOI:10.1515/pac-2019-1211

  Gerringer M.E., Yancey P.H., Tikhonova O.V., Vavilov N.E., Zgoda V.G., Davydov D.R. (2020) Pressure tolerance of deep-sea enzymes can be evolved through increasing volume changes in protein transitions: a study with lactate dehydrogenases from abyssal and hadal fishes, FEBS Journal, 287(24), 5394-5410. DOI:10.1111/febs.15317

  Serkova O.S., Kamkina A.V., Toropygin I.Yu., Maslennikova V.I. (2020) Polyfunctional chelate derivatives of dinaphthylmethane and resorcincalix[4]arene: synthesis, relationship between chelate structure and its acceptor ability, Russian Journal of General Chemistry, 90(8), 1466-1473. DOI:10.1134/S1070363220080137

  Afoshin A.S., Konstantinov M.A., Toropygin I.Y., Kudryakova I.V., Vasilyeva N.V. (2020) β-Lytic Protease of Lysobacter capsici VKM B-2533T, Antibiotics, 9(11), 744. DOI:10.3390/antibiotics9110744

  Serkova O.S., Glushko V.V., Toropygin I.Yu., Maslennikova V.I. (2020) Synthesis of Triazole-Containing rctt Tetra-C-Naphthyl-Calix [4]resorcinarene and 1,1-Dinaphthylmethane Derivatives, ChemistrySelect, 39(5), 12168-12175. DOI:10.1002/slct.202003503

  Finkina E.I., Melnikova D.N., Bogdanov I.V., Matveevskaya N.S., Ignatova A.A., Toropygin I.Y., Ovchinnikova T.V. (2020) Impact of different lipid ligands on the stability and ige-binding capacity of the lentil allergen len c 3, Biomolecules, 10(12), 1668. DOI:10.3390/biom10121668

  Maltseva D.V., Raigorodskaya M.P., Tikhonova O.V., Knyazev E.N., Tonevitsky E.A. (2020) Relationship between the Expression Level of PSMD11 and Other Proteasome Proteins with the Activity of Ricin and Viscumin, Doklady Biochemistry and Biophysics, 493(1), 198-200. DOI:10.1134/S1607672920040080

  Kopylov A.T., Ponomarenko E.A., Ilgisonis E.V., Pyatnitskiy M.A., Lisitsa A.V., Poverennaya E.V., Kiseleva O.I., Farafonova T.E., Tikhonova O.V., Zavialova M.G., Novikova S., Moshkovskii S.A., Radko S.P., Morukov B.V., Grigoriev A.I., Paik Y.K., Salekdeh G.H., Urbani A., Zgoda V.G., Archakov A.I. (2019) 200+ Protein Concentrations in Healthy Human Blood Plasma: Targeted Quantitative SRM SIS Screening of Chromosomes 18, 13, Y and the Mitochondrial Chromosome Encoded Proteome, Journal of Proteome Research, 18(1), 120-129. DOI:10.1021/acs.jproteome.8b00391

  Zubkova E.S., Beloglazova I.B., Evtushenko E.G., Kopylov A.T., Shevchenko E.K., Dergilev K.V., Ratner E.I., Parfenova E.V., Men`shikov M.Yu. (2019) Application of Adeno-Associated Virus Vectors for Engineering SCF-Containing Extracellular Vesicles of Mesenchymal Stromal Cells, Bulletin of Experimental Biology and Medicine, 166(4), 527-534. DOI:10.1007/s10517-019-04387-2

  Kasabov K.A., Shakhovtsev D.A., Malyshev N.V., Konstantinov M.A., Narkevich V.B., Kudrin V.S., Anderzhanova E.A. (2019) Changes in Monoamine Levels in BALB/c and 57Bl/6N Mice in Response to Acute Stress with Different Controllability, Bulletin of Experimental Biology and Medicine, 167(5), 610-615. DOI:10.1007/s10517-019-04581-2

  Zlobin N., Evlakov K., Tikhonova O., Babakov A., Taranov V. (2018) RNA melting and RNA chaperone activities of plant cold shock domain proteins are not correlated, RNA biology, 15(8), 1040-1046. DOI:10.1080/15476286.2018.1506681

  Ilgisonis E.V., Kopylov A.T., Ponomarenko E.A., Poverennaya E.V., Tikhonova O.V., Farafonova T.E., Novikova S., Lisitsa A.V., Zgoda V.G., Archakov A.I. (2018) Increased Sensitivity of Mass Spectrometry by Alkaline Two-Dimensional Liquid Chromatography: Deep Cover of the Human Proteome in Gene-Centric Mode, Journal of Proteome Research, 17(12), 4258-4266. DOI:10.1021/acs.jproteome.8b00754

  Poverennaya E.V., Kopylov A.T., Ponomarenko E.A., Ilgisonis E.V., Zgoda V.G., Tikhonova O.V., Novikova S.E., Farafonova T.E., Kiseleva Y.Y., Radko S.P., Vakhrushev I.V., Yarygin K.N., Moshkovskii S.A., Kiseleva O.I., Lisitsa A.V., Sokolov A.S., Mazur A.M., Prokhortchouck E.B., Skryabin K.G., Kostrjukova E.S., Tyakht A.V., Gorbachev A.Y., Ilina E.N., Govorun V.M., Archakov A.I. (2016) State of the Art on Chromosome 18-centric HPP in 2016: Transcriptome and Proteome Profiling of Liver Tissue and HepG2 Cells, Journal of Proteome Research, 15(11), 4030-4038. DOI:10.1021/acs.jproteome.6b00380

  Kopylov A.T., Ilgisonis E.V., Moysa A.A., Tikhonova O.V., Zavialova M.G., Novikova S.E., Lisitsa A.V., Ponomarenko E.A., Moshkovskii S.A., Markin A.A., Grigoriev A.I., Zgoda V.G., Archakov A.I. (2016) Targeted Quantitative Screening of Chromosome 18 Encoded Proteome in Plasma Samples of Astronaut Candidates, Journal of Proteome Research, 15(11), 4039-4046. DOI:10.1021/acs.jproteome.6b00384