Laboratory of Structural Proteomics
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Kristina A. Malsagova Ph.D.
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RESEARCH
Organization of a biorepository for the purpose of obtaining and analyzing data on the molecular composition of biological samples, their digitization and storage.
Research in the field of molecular bases of development of diseases, creation of a molecular and genetic regression model as the basis for personalized prediction of cancer and mental diseases. Evaluation of the stability of structural motifs in globular proteins with posttranslational modifications associated with the development of oncological diseases. Development of comparative immunoassay methods for detecting allergens of hidden food intolerance. Development of targets for the potential creation of test systems for the purpose of diagnostics of oncological diseases.
Nikolsky K.S., Kopylov A.T., Nakhod V.I., Potoldykova N.V., Enikeev D.V., Butkova T.V., Kulikova L.I., Malsagova K.A., Rudnev V.R., Petrovsky D.V., Izotov A.A., Kaysheva A.L. (2025) Plasma proteome fingerprint in kidney diseases, Frontiers in Molecular Biosciences, 11, 1494779. DOI:10.3389/fmolb.2024.1494779
Petrovskiy D.V., Nikolsky K.S., Kulikova L.I., Rudnev V.R., Butkova T.V., Malsagova K.A., Kopylov A.T., Kaysheva A.L. (2024) PowerNovo: de novo peptide sequencing via tandem mass spectrometry using an ensemble of transformer and BERT models, Scientific Reports, 14(1), 15000. DOI:10.1038/s41598-024-65861-0
Petrovsky D.V., Butkova T.V., Nikolsky K.S., Kopylov A.T., Nakhod V.I., Kulikova L.I., Malsagova K.A., Kibrik N.D., Rudnev V.R., Izotov A.A., Kaysheva A.L. (2024) Extended range proteomic analysis of blood plasma from schizophrenia patients, Frontiers in Molecular Biosciences, 11, 1483933. DOI:10.3389/fmolb.2024.1483933
Malsagova K.A., Kopylov A.T., Stepanov A.A., Enikeev D.V., Potoldykova N.V., Balakin E.I., Pustovoyt V.I., Kaysheva A.L. (2023) Molecular Profiling of Athletes Performing High-Intensity Exercises in Extreme Environments, Sports, 11(2), 36. DOI:10.3390/sports11020036
Kopylov A.T., Stepanov A.A., Butkova T.V., Malsagova K.A., Zakharova N.V., Kostyuk G.P., Elmuratov A.U., Kaysheva A.L. (2023) Consolidation of metabolomic, proteomic, andGWAS data in connective model of schizophrenia, Scientific Reports, 13(1), 2139. DOI:10.1038/s41598-023-29117-7
Stepanov A.A., Malsagova K.A., Kopylov A.T., Rudnev V.R., Karateev D.E., Markelova E.I., Luchikhina E.L., Borisova E.E., Kaysheva A.L. (2023) Determination of Heterogeneous Proteomic and Metabolomic Response in anti-TNF and anti-IL-6 Treatment of Patients with Rheumatoid Arthritis, Life, 13(2), 596. DOI:10.3390/life13020596
Petrovskiy D.V., Nikolsky K.S., Rudnev V.R., Kulikova L.I., Butkova T.V., Malsagova K.A., Kopylov A.T., Kaysheva A.L. (2023) Modeling Side Chains in the Three-Dimensional Structure of Proteins for Post-Translational Modifications, International Journal of Molecular Sciences, 24(17), 13431-13431. DOI:10.3390/ijms241713431
Nikolsky K.S., Kulikova L.I., Petrovskiy D.V., Rudnev V.R., Butkova T.V., Malsagova K.A., Kopylov A.T., Kaysheva A.L. (2023) Three-helix bundle and SH3-type barrels: autonomously stable structural motifs in small and large proteins, Journal of Biomolecular Structure & Dynamics, 42(17), 9090-9104. DOI:10.1080/07391102.2023.2250450
Petrovsky D.V., Pustovoyt V.I., Nikolsky K.S., Malsagova K.A., Kopylov A.T., Stepanov A.A., Rudnev V.R., Balakin E.I., Kaysheva A.L. (2022) Tracking Health, Performance and Recovery in Athletes Using Machine Learning, Sports, 10(10), 160. DOI:10.3390/sports10100160
Kopylov A.T., Petrovsky D.V., Stepanov A.A., Rudnev V.R., Malsagova K.A., Butkova T.V., Zakharova N.V., Kostyuk G.P., Kulikova L.I., Enikeev D.V., Potoldykova N.V., Kulikov D.A., Zulkarnaev A.B., Kaysheva A.L. (2021) Convolutional neural network in proteomics and metabolomics for determination of comorbiity between cancer and schizophrenia, Journal of Biomedical Informatics, 122, 103890. DOI:10.1016/j.jbi.2021.103890
- Petrovsky D.V., Nikolsky K.S., Kulikova L.I., Rudnev V.R., Kaisheva A.L. Method for de novo sequencing of amino acid sequences.
- Kopylov A. T., Ilgisonis E. V., Kaysheva A. L., Moshkovsky S. A., Filimonov A.D., Romashova Yu. a., Zgoda V. G., Lisitsa A.V., Archakov A. I. Creating the foundations of ultra-sensitive detection of bacterial DNA/RNA using electrochemical (bio)sensors. Patent RU2013134985A Method for obtaining an analytical test system for multiplex identification and quantitative measurement of the content of proteins of interest in a biological sample based on the content of their corresponding proteotypic marker peptides.
- Butkova T. V. Method of treatment of erectile disorders and disorders of sexual desire. The patent for the invention №2483742. Application no. 2012130312 dated June 10, 2013.
- Ivanov Yu.D., Pleshakova T.O., Malsagova K.A., Kozlov A.F., Archakov A.I., Popov V.P. Method for breast cancer and ovarian cancer diagnosis. Patent RU2696114C2 dated 07/31/2019.